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Block copolymers composed of poly 3-hydroxyoctanoate PHO and methoxy poly ethylene glycol PEG were synthesized to prepare paclitaxel-incorporated nanoparticle for antitumor drug delivery. The higher M. The higher drug feeding increased drug contents and average size of nanoparticles. In the drug release study, the higher M.
The increase in drug contents induced the slow release rate of drug. In an antitumor activity study in vitropaclitaxel nanoparticles have practically similar anti-proliferation activity against HCT human colon carcinoma cells.
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In an in vivo animal study using HCT colon carcinoma cell-bearing mice, paclitaxel nanoparticles have enhanced antitumor activity compared anh paclitaxel itself.
Nanoparticles; Block copolymer; Poly 3-hydroxyoctanoate ; Drug jenh. Nonvolatile memory technologies in Si-based electronics date back to the s.